Role of Cdc42 dynamics in the control of fission yeast cell polarization.
نویسندگان
چکیده
Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and time-delayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.
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عنوان ژورنال:
- Biochemical Society transactions
دوره 41 6 شماره
صفحات -
تاریخ انتشار 2013