Role of Cdc42 dynamics in the control of fission yeast cell polarization.

نویسندگان

  • Maitreyi Das
  • Fulvia Verde
چکیده

Cell polarization is fundamental to many cellular processes, including cell differentiation, cell motility and cell fate determination. A key regulatory enzyme in the control of cell morphogenesis is the conserved Rho GTPase Cdc42, which breaks symmetry via self-amplifying positive-feedback mechanisms. Additional mechanisms of control, including competition between different sites of polarized cell growth and time-delayed negative feedback, define a cellular-level system that promotes Cdc42 oscillatory dynamics and modulates activated Cdc42 intracellular distribution.

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عنوان ژورنال:
  • Biochemical Society transactions

دوره 41 6  شماره 

صفحات  -

تاریخ انتشار 2013